Biosciences - Team Pasteur

René Raggers studied molecular biology in Groningen, worked at the ETH in Zurich, Switzerland and obtained his doctorate with a thesis on cell biology research on cancer at the Amsterdam Medical Center. He also majored in business administration. René has been with EP&C since 1995. Previously, he was responsible for scientific innovation in product development in the food industry.

René is tenacious, diplomatic, cheerful and quick. “As an attorney you have to be able to think along with your client. My work has to be useful and effective for my client, not only when applying for patent-rights, or enforcing patent-right, but also in case of problems with the patent-right of others. I will do whatever it takes to optimally protect my client’s rights.”

Sientific publications

Raggers RJ, Vogels I, Van Meer G. Upregulation of the expression of endogenous Mdr1 P-glycoprotein enhances lipid translocation in MDCK cells transfected with human MRP2. Histochem Cell Biol. 2002 Feb;117(2):181-5.

Holthuis JC, Pomorski T, Raggers RJ, Sprong H, Van Meer G. The organizing potential of sphingolipids in intracellular membrane transport. Physiol Rev. 2001 Oct;81(4):1689-723.

Raggers RJ, Vogels I, Van Meer G. Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. Biochem J. 2001 Aug 1;357(Pt 3):859-65.

Raggers RJ, Pomorski T, Holthuis JC, Kalin N, Van Meer G. Lipid traffic: the ABC of transbilayer movement. Traffic. 2000 Mar;1(3):226-34.

Sillence DJ, Raggers RJ, Van Meer G. Assays for transmembrane movement of sphingolipids. Methods Enzymol. 2000;312:562-79.

Sillence DJ, Raggers RJ, Neville DC, Harvey DJ, Van Meer G. Assay for the transbilayer distribution of glycolipids. Selective oxidation of glucosylceramide to glucuronylceramide by TEMPO nitroxyl radicals. J Lipid Res. 2000 Aug;41(8):1252-60.

Van Meer G, Sillence D, Sprong H, Kalin N, Raggers R. Transport of (glyco)sphingolipids in and between cellular membranes; multidrug transporters and lateral domains. Biosci Rep. 1999 Aug;19(4):327-33.

Raggers RJ, van Helvoort A, Evers R, Van Meer G. The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane. J Cell Sci. 1999 Feb;112 ( Pt 3):415-22.

Van den Bergh ER, Baker SC, Raggers RJ, Terpstra P, Woudstra EC, Dijkhuizen L, Meijer WG. Primary structure and phylogeny of the Calvin cycle enzymes transketolase and fructosebisphosphate aldolase of Xanthobacter flavus. J Bacteriol. 1996 Feb;178(3):888-93.