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Your Business First



"I am able to put myself in the shoes of both biologists and technicians."

Fed by his fascination with biology, medicine and medical technology, Michiel Croes studied Technical Medicine at the University of Twente. During this time, he learned to easily adapt to the ways in which doctors, technicians and biologists interact and work. Not surprisingly, his PhD and postdoctoral research at the UMC Utrecht was of a very multidisciplinary nature, combining clinical research, materials science, immunology, and micro- and cell biology.

Michiel has been part of EP&C since 2021. The reason for his move to intellectual property law was his growing interest in the commercial activities of biotech and medtech startups, patent law, and his experiences with an invention of his own during his research.

Thanks to that invention, Michiel got to know the world of startups, incubators and financial backers from an inventor's perspective. Now, he is immersing himself in the work of a protector. With a focus on life sciences and medical technology, he likes to take clients through the process that he himself knows so well from both sides. "I deal with scientists and people with commercial ambitions. Thanks to my training and the projects around it, I am able to easily relate to both of them."


Read all of Michiel's blog posts

Scientific publications

Fatemeh Jahanmard, Azin Khodaei, Jip Flapper, Ozan Dogan, Khatereh Roohi, Peyman Taheri, Harrie Weinans, Gert Storm, Michiel Croes, E Mastrobattista, Saber Amin Yavari (2023). Osteoimmunomodulatory Gelma/Liposome Coatings to Promote Bone Regeneration of Orthopedic Implants. Journal of Controlled Release. Volume 358, 667-680

Leonardo Cecotto, Daphne AC Stapels, Kok PM van Kessel, Michiel Croes, Zeldali Lourens, H Charles Vogely, Bart CH van der Wal, Jos AG Van Strijp, Harrie Weinans, Saber Amin Yavari (2023). Evaluation of silver bio-functionality in a multicellular in vitro model: towards reduced animal usage in implant-associated infection research. Front Cell Infect Microbiol. 13, 1186936.

Paree Khokhani, Nada R Rahmani, Carissa Hing-Wai Wong, Keith Yu-Kin Cheng, Wing-Hoi Cheung, Simon Kwoon-Ho Chow, F Cumhur Oner, Rene M Castelein, Saber Amin Yavari, Jacqueline Alblas, Harrie Weinans, Moyo C Kruyt, Michiel Croes (2022). Nucleic-acid based pathogen recognition receptor ligands enhance osteogenesis via immunomodulation. Tissue Engineering Part A. 28, S540-S541

Paree Khokhani, Ruggero Belluomo, Michiel Croes, Debby Gawlitta, Moyo C Kruyt, Harrie Weinans (2022).  An In Vitro Model to Test the Influence of Immune Cell Secretome on Mesenchymal Stromal Cell Osteogenic Differentiation. Tissue Engineering Part C: Methods 28 (8), 420-430

Khokhani, P., Rahmani, N. R., Kok, A., Öner, F. C., Alblas, J., Weinans, H., & Croes, M. (2021). Use of therapeutic pathogen recognition receptor ligands for osteo-immunomodulation. Materials14(5), 1119.

Amin Yavari, S., Castenmiller, S. M., van Strijp, J. A., & Croes, M. (2020). Combating implant infections: shifting focus from bacteria to host. Advanced Materials32(43), 2002962.

Jahanmard, F., Croes, M., Castilho, M., Majed, A., Steenbergen, M. J., Lietaert, K., & Yavari, S. A. (2020). Bactericidal coating to prevent early and delayed implant-related infections. Journal of Controlled Release326, 38-52.

Croes, M., Akhavan, B., Sharifahmadian, O., Fan, H., Mertens, R., Tan, R. P., & Yavari, S. A. (2020). A multifaceted biomimetic interface to improve the longevity of orthopedic implants. Acta biomaterialia110, 266-279.

Croes, M., van der Wal, B. C., & Vogely, H. C. (2019). Impact of bacterial infections on osteogenesis: evidence from in vivo studies. Journal of Orthopaedic Research®37(10), 2067-2076.

Croes, M., Kruyt, M. C., Boot, W., Pouran, B., Braham, M. V., Pakpahan, S. A., & Öner, F. C. (2019). The role of bacterial stimuli in inflammation-driven bone formation. European cells & materials37, 402-419.

Yavari, S. A., Croes, M., Akhavan, B., Jahanmard, F., Eigenhuis, C. C., Dadbakhsh, S., & Zadpoor, A. A. (2020). Layer by layer coating for bio-functionalization of additively manufactured meta-biomaterials. Additive Manufacturing32, 100991.

Akhavan, B., Croes, M., Wise, S. G., Zhai, C., Hung, J., Stewart, C., & Bilek, M. M. (2019). Radical-functionalized plasma polymers: Stable biomimetic interfaces for bone implant applications. Applied Materials Today16, 456-473.

Jahanmard, F., Eslaminejad, M. B., Amani-Tehran, M., Zarei, F., Rezaei, N., Croes, M., & Yavari, S. A. (2020). Incorporation of F-MWCNTs into electrospun nanofibers regulates osteogenesis through stiffness and nanotopography. Materials Science and Engineering: C106, 110163.

Loozen, L. D., Kruyt, M. C., Kragten, A. H., Schoenfeldt, T., Croes, M., Oner, C. F., & Alblas, J. (2019). BMP-2 gene delivery in cell-loaded and cell-free constructs for bone regeneration. Plos one14(7), e0220028.

Croes, M., Bakhshandeh, S., Van Hengel, I. A. J., Lietaert, K., Van Kessel, K. P. M., Pouran, B., & Yavari, S. A. (2018). Antibacterial and immunogenic behavior of silver coatings on additively manufactured porous titanium. Acta biomaterialia81, 315-327.

Croes, M., Kruyt, M. C., Groen, W. M., Van Dorenmalen, K. M. A., Dhert, W. J. A., Öner, F. C., & Alblas, J. (2018). Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation. Scientific reports8(1), 1-13.

Loozen, L. D., Kruyt, M. C., Vandersteen, A., Kragten, A. H., Croes, M., Öner, F. C., & Alblas, J. (2018). Osteoinduction by Ex Vivo Nonviral Bone Morphogenetic Protein Gene Delivery Is Independent of Cell Type. Tissue Engineering Part A24(19-20), 1423-1431.

Bastian, O. W., Croes, M., Alblas, J., Koenderman, L., Leenen, L. P., & Blokhuis, T. J. (2018). Neutrophils inhibit synthesis of mineralized extracellular matrix by human bone marrow-derived stromal cells in vitro. Frontiers in immunology9, 945.

Croes, M., De Visser, H., Meij, B. P., Lietart, K., Van der Wal, B. C. H., Vogely, H. C., & Yavari, S. A. (2018). Data on a rat infection model to assess porous titanium implant coatings. Data in brief21, 1642-1648.

Croes, M., Kruyt, M. C., Loozen, L., Kragten, A., Yuan, H., Dhert, W. J., & Alblas, J. (2017). Local induction of inflammation affects bone formation. European cells & materials33, 211-226.

Croes, M., Boot, W., Kruyt, M. C., Weinans, H., Pouran, B., van der Helm, Y. J., & Öner, F. C. (2017). Inflammation-induced osteogenesis in a rabbit tibia model. Tissue Engineering Part C: Methods23(11), 673-685.

Croes, M., Öner, F. C., van Neerven, D., Sabir, E., Kruyt, M. C., Blokhuis, T. J., & Alblas, J. (2016). Proinflammatory T cells and IL-17 stimulate osteoblast differentiation. Bone84, 262-270.

Croes, M., Oner, F. C., Kruyt, M. C., Blokhuis, T. J., Bastian, O., Dhert, W. J., & Alblas, J. (2015). Proinflammatory mediators enhance the osteogenesis of human mesenchymal stem cells after lineage commitment. PloS one10(7), e0132781.